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CHEM 415     Mechanistic Enzymology  (4)

An examination, from an organic mechanistic perspective, of traditional and non-traditional uses of coenzymes in enzymatic catalysis. Particular emphasis is placed on the experimental methods used to provide evidence for proposed mechanistic pathways such as the use of isotopic labels and fluorinated substrate analogues as well as assorted spectroscopic techniques. Additional topics include the biosynthesis of various classes of secondary metabolites such as polyketides, terprenes, and deoxysugars. Prerequisite: CHEM 202.