Chemistry

Website: chemistry.sewanee.edu

Chemistry is often referred to as the central science. As such, it interfaces with and illuminates numerous disciplines including physics, biology, forestry, and geology. The general chemistry course attempts to serve future majors and students from these other disciplines by providing a solid foundational understanding of the central organizational principles of chemistry. Courses in the major amplify this understanding by providing an in-depth exploration of the major sub-disciplines: organic, inorganic, analytical, environmental, physical and biochemistry. Majors are encouraged to participate in research projects with faculty members, during the school year and in the summer. Majors are also encouraged to participate in research groups at other schools during the summers. An active seminar series allows students to gain proficiency in oral presentation of technical material as well as learn about the frontiers of chemical research from eminent scientists.

Entering students with an interest in the chemistry major are strongly encouraged to discuss their academic planning with faculty in the Department of Chemistry as early as possible in their academic career.

Professors: Bachman, Durig, Miles

Associate Professors: Pongdee, B. Seballos, Shibata, R. Summers (Chair)

Assistant Professors: Joslin, L. Seballos

Requirements for the Major in Chemistry

The major requires successful completion of the following:

Course Requirements
CHEM 120General Chemistry (Lab) 14
or CHEM 150 Advanced General Chemistry (Lab)
CHEM 201Organic Chemistry I (Lab) 24
CHEM 202Organic Chemistry II (Lab)4
CHEM 210Solution and Solid State Chemistry (Lab)4
CHEM 301Junior Seminar2
CHEM 307Mechanistic Biochemistry (Lab)4
or CHEM 316 Biochemistry of Metabolism and Molecular Biology (Lab)
CHEM 308Inorganic Chemistry (Lab)4
CHEM 311Instrumental Analysis (Lab)4
CHEM 352Thermodynamics and Kinetics (Lab)4
CHEM 401Senior Seminar2
Select one additional course in chemistry (CHEM) numbered above 4014
MATH 102Calculus II 34
Select one of the following:8
General Physics I (Lab)
and General Physics II (Lab)
Modern Mechanics (Lab)
and Electric and Magnetic Interactions (Lab)
Total Semester Hours52
Additional Requirements
A comprehensive examination

Honors

In order to receive honors in chemistry, a student must have a 3.00 or higher GPA in the major, take two advanced electives in chemistry at the 400 level, and complete a research project that the chemistry faculty considers worthy of honors. The research project may be done as part of a course (usually CHEM 494), or it may be done in the context of a summer research program at this University or at another institution. The honors project must involve some original work. A formal written report and a seminar presentation on the research are required. Students must inform the department of their intention to seek honors no later than the middle of the first semester of their senior year. Please see the departmental web page for additional information about honors.

Requirements for the Minor in Chemistry

The minor requires successful completion of the following:

Course Requirements
CHEM 120General Chemistry (Lab)4
or CHEM 150 Advanced General Chemistry (Lab)
CHEM 201Organic Chemistry I (Lab)4
CHEM 202Organic Chemistry II (Lab)4
Select two of the following:8
Solution and Solid State Chemistry (Lab)
Mechanistic Biochemistry (Lab)
Inorganic Chemistry (Lab)
Instrumental Analysis (Lab)
Thermodynamics and Kinetics (Lab)
Total Semester Hours20

Chemistry Courses

CHEM 100     Foundations of Chemistry  (4)

This course explores the foundational principles of chemistry within the context of contemporary topics in the chemical sciences and society. In addition to introducing the central models and theories of chemistry, the course develops a student's skills in analytical reasoning and problem-solving.

CHEM 110     The Science of Food and Cooking  (4)

An introduction to the science of food and food preparation. Students learn the scientific method through the examination of food and cooking in the laboratory setting. Recent food-related controversies, such as low-carbohydrate diets, are considered. The course is designed for the general student. Open only to new first-year students.

CHEM 112     Chemistry of Art and Artifacts  (4)

This course addresses both of these intersections between science and the arts by considering the role of chemistry in the production and interpretation of art and artifacts from theoretical and practical perspectives. The course also examines the application of chemistry to art conservation and archaeology.

CHEM 114     Life, Energy, and the Atomic Bomb: How the Science of Metals Shapes Society  (4)

This course provides an understanding of how chemistry and metals influence everyday lives. Using the periodic table as a touchstone, the course examines the role of metals and their chemistry in society. Specific themes include the use of metals in medicine and health; the role of metals in the production of modern materials and products; the use of metals in both traditional and alternative fuels; and the ways in which metals have been used to influence global political power through the atomic bomb and other devices.

CHEM 120     General Chemistry (Lab)  (4)

A survey of the basic chemical principles and theories, with emphasis on applying these concepts to chemically related fields such as environmental science and biological chemistry. Topics considered include atomistic and molecular structure, kinetics, thermodynamics, and chemical equilibrium. The course's laboratory portion emphasizes the collection and interpretation of data, as well as the formation and testing of hypotheses. Lecture, three hours; laboratory, three hours. Prerequisite: One course with attribute G5, G5E, or G5Q or placement.

CHEM 150     Advanced General Chemistry (Lab)  (4)

An introduction to fundamental chemical concepts with an emphasis on understanding and analytical reasoning. The course focuses on the molecular basis of matter and its transformation as well as the role of chemistry in the broader scientific and societal enterprise. The laboratory portion of the course emphasizes the collection and interpretation of empirical data. This course is intended for students with a significant background and interest in the chemical sciences. Open only to new first-year students. Prerequisite: Chemistry 100 or placement.

CHEM 201     Organic Chemistry I (Lab)  (4)

A study of the nomenclature and the properties of the most important classes of organic compounds with an emphasis on concepts relating molecular structure and properties. Stereochemistry, functional group transformations and reaction mechanisms are studied in depth. Lecture, three hours; laboratory, three hours. Prerequisite: CHEM 102 or CHEM 111 or CHEM 120 or CHEM 150.

CHEM 202     Organic Chemistry II (Lab)  (4)

A continuation of CHEM 201. A portion of the course is devoted to the study of important classes of biochemical compounds. Lecture, three hours; laboratory, three hours. Prerequisite: CHEM 201.

CHEM 210     Solution and Solid State Chemistry (Lab)  (4)

Solution and solid chemistry is fundamental in a variety of contexts from biological to geological systems. This course explores the behavior of these systems as well as applications of chemical theory in a variety of contexts. Students engage in a studio laboratory to gain experience with the measurements and analysis necessary to characterize both solution and solid samples. Prerequisite: CHEM 120 or CHEM 150.

CHEM 301     Junior Seminar  (2)

A series of lectures by faculty, students, and invited speakers. Junior majors will give talks on topics agreed upon with a faculty mentor. Talks describing student research are encouraged. Open only to juniors pursuing majors in chemistry.

CHEM 307     Mechanistic Biochemistry (Lab)  (4)

An examination of all aspects of protein science, including protein biosynthesis, protein structure, and the mechanisms of enzyme catalysis, with particular emphasis on the biochemistry of enzyme catalysis. Lecture, three hours; laboratory, three and one-half hours. Prerequisite: CHEM 202.

CHEM 308     Inorganic Chemistry (Lab)  (4)

A detailed examination of the chemistry of the elements, with a particular emphasis on structure and bonding, structure-property relationships, and reaction energetics. Course topics include organometallics and catalysis, aquatic chemistry of the metals, solid-state chemistry, and the role of metals in biology. Prerequisite: CHEM 201 and CHEM 210.

CHEM 311     Instrumental Analysis (Lab)  (4)

An introduction to the theory and practice of the fundamental principles of chemical analysis and the use of chemical instrumentation in research. Course topics include spectrophotometric and spectroscopic methods; electrochemical fundamentals and electroanalytical techniques; chromatographic and separation methods; and statistical analysis of data. Prerequisite: CHEM 210.

CHEM 316     Biochemistry of Metabolism and Molecular Biology (Lab)  (4)

A study of the biochemical reactions of eukaryotic cellular metabolism and bioenergetics, focusing on enzyme regulation and function, protein structure, nucleic acid structure and function, and selected topics in molecular biology and physiological biochemistry. Prior coursework in cell/molecular biology is recommended. Laboratory course. Prerequisite: BIOL 233 and CHEM 202 and BIOL 243.

CHEM 352     Thermodynamics and Kinetics (Lab)  (4)

An introduction to thermodynamics and kinetics. Prerequisite: CHEM 201 and MATH 102. Prerequisite or Corequisite: PHYS 101 or PHYS 103.

CHEM 401     Senior Seminar  (2)

A series of lectures by faculty, students, and invited speakers. Senior majors will give talks on topics agreed upon with a faculty mentor. Talks describing student research are encouraged. Open only to seniors pursuing majors in chemistry.

CHEM 405     Organic Synthesis  (4)

A comprehensive study of modern organic reactions and their application to the synthesis of biologically-active natural products. Prerequisite: CHEM 202.

CHEM 408     Advanced Topics in Inorganic Chemistry  (4)

Selected topics in modern inorganic chemistry, such as bioinorganic chemistry, materials chemistry, and organometallic chemistry. The course surveys relevant primary literature. Topics may vary from year to year, and the course may be repeated for credit, depending upon the topic. Lecture, three hours. Prerequisite: CHEM 308.

CHEM 412     Advanced Environmental Geochemistry  (4)

An examination of the chemical principles that determine how natural systems work and how anthropogenic activities can have an impact on the function of these systems. Topics include both fundamental chemical principles and case studies of particular environmental systems. Lecture, three hours. Prerequisite: CHEM 120 or CHEM 150.

CHEM 415     Mechanistic Enzymology  (4)

An examination, from an organic mechanistic perspective, of traditional and non-traditional uses of coenzymes in enzymatic catalysis. Particular emphasis is placed on the experimental methods used to provide evidence for proposed mechanistic pathways such as the use of isotopic labels and fluorinated substrate analogues as well as assorted spectroscopic techniques. Additional topics include the biosynthesis of various classes of secondary metabolites such as polyketides, terprenes, and deoxysugars. Prerequisite: CHEM 202.

CHEM 417     Advanced Biochemistry  (4)

An exploration of contemporary issues in biochemistry based largely on primary literature. Topics such as the biosynthesis and mode of action of antibiotics, protein engineering, signal transduction, chemical carcinogenesis, and isotope effects in enzyme kinetics will be addressed in detail. Prerequisite: BIOL 306 or BIOL 307 or CHEM 316 or CHEM 306 or CHEM 307.

CHEM 418     Structural Methods  (4)

This course examines the theory and praxis of molecular and macromolecular structure determination via spectroscopic and physical methods. Lecture, three hours. Prerequisite: CHEM 202.

CHEM 422     Quantum Chemistry and Spectroscopy  (4)

An introduction to quantum mechanics in chemistry and spectroscopy. Lecture, three hours. Prerequisite: CHEM 201 and MATH 102 and (PHYS 102 or PHYS 104).

CHEM 424     Topics in Physical Chemistry  (4)

Prerequisite: (CHEM 120 or CHEM 150) and (MATH 102 or MATH 207) and (PHYS 102 or PHYS 104).

CHEM 425     Drug Design and Development  (4)

An examination of the fundamental chemical aspects associated with the process of discovering new drugs. Both combinatorial and rational drug design methodologies are addressed. Emphasis is on the application of various structure-based and mechanism-based strategies for drug optimization. Additional topics include pharmacokinetics (how drugs move within the body), metabolism of drugs, and pharmacodynamics (effect of drugs and their molecular mechanism of action). Prerequisite: CHEM 202.

CHEM 428     Advanced Topics in Analytical Chemistry  (4)

This course covers the theory and practice of analytical techniques and recent advances in the field. Prerequisite: CHEM 311.

CHEM 444     Directed Readings  (2 or 4)

An in-depth investigation of an advanced topic or topics in chemistry conducted through readings from the primary and secondary literature and discussion with faculty mentor. Repeatable for credit. Prerequisite: Professor consent and prerequisite override required.

CHEM 494     Mentored Research  (2 or 4)

Students engage in original research in chemistry under the mentorship of a faculty member. Students apply and integrate knowledge from their coursework while learning both specific laboratory techniques and practical problem-solving skills. Discussion of proper laboratory record-keeping, responsible conduct of research, presentation of research results, and laboratory safety are also emphasized. Repeatable for credit. Prerequisite: Professor consent and prerequisite override required.